Kalmar "prefrontal leukotomy" tana nufin aikin tiyata wanda ya ƙunshi cirewa ko lalata nama a cikin prefrontal cortex na kwakwalwa. Tun asali an yi amfani da shi azaman magani ga matsananciyar tabin hankali kamar schizophrenia da damuwa, kodayake an yi watsi da shi sosai saboda samun ƙarin magunguna masu inganci da yuwuwar haifar da mummunan sakamako.